People die. More to the point, people die in Mass Effect. Most players experience this in Mass Effect 1 when Wrex dies. I had enough Paragon points to talk Wrex down and keep him alive. I’ve heard heartfelt stories from other players who were really attached to crew members who died, specifically in Mass Effect 2. Having this bit of information, I confess I cheated a little and kept my two favorite characters, Garrus and Tali’Zorah, close to me during the final mission. I didn’t care if Jacob or Miranda took a Collector beam to the chest. I liked Mordin though. I found him entertaining in a queer useful sort of way.  Unfortunately, the poor loquacious salamander-scientist didn’t make it.

NO SPOILERS PLEASE!
Progress: Probably about 60% of the way through Mass Effect 3.